Maze Therapeutics

the power of genetics

our strategy – applying variant functionalization to precision medicine

Using the tools of modern human genetics, the scientific community is learning how variations in different genes may impact disease at an unprecedented pace.

We believe that we are pioneering the effort to translate genetic insights into therapeutic innovations by leveraging the technological convergence between biological sciences and information technology, and that our approach to drug discovery and development significantly mitigates its inherent risks with the key feature of variant functionalization.

Our strategy focuses on advancing precision medicines to address common diseases across renal and cardio-metabolic indications. To do this, we are applying insights in genetics, combined with our area expertise and Maze Compass™ platform to maximize the long-term impact we can have on worldwide human health.

Renal Disease

CKD estimated to impact ~10% of the world population (~700M) and ~37M in the U.S.; high risk APOL1 gene varients most prevalent in people of West African ancestry.

Cardio-Metabolic Disease

Cardio-Metabolic diseases, including cardiovascular disease, diabetes, obesity and kidney failure, are the #1 cause of death worldwide, with an estimated >30% of risk attributable to genetics.

Applying variant functionalization to precision medicine

Leveraging our area expertise, variant functionalization and Maze Compass Platform, to maximize impact on worldwide human health.

Maze Compass™ Platform

Maze has developed the Maze Compass™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development.

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