Maze Therapeutics

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our people

At Maze, our number one focus is people – from the patients we work tirelessly to help to the families whose genetic modifiers inspire our therapies to the members of our team who embrace our mission.

Enter the maze

Our team is comprised of world class scientists and experienced company builders who have an unparalleled commitment to changing the way people with devastating diseases are treated.

We are always looking for talented and creative people to join us in our mission. Interested in working at Maze? Please email careers@mazetx.com

job openings

Senior Bioinformatics Software Engineer

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated senior-level Software Engineer to help lead in the development of our genetic discovery platform. The successful candidate will join a team of computational biologists, systems architects and automation engineers to mobilize genetics and functional genomics data towards the discovery of new therapeutic targets and drugs.

Your Role in Navigating The Maze:

  • You will help design and build the software development ecosystem for the company.
  • You will work with Data Science, Human Genetics, Research Biology and Drug Development groups to implement production-quality, cutting-edge analytical methods
  • You will design, deploy and maintain robust tools for data management, analysis and communication.
  • You will lead the building of production-quality, scalable bioinformatics and genomics pipelines.
  • You will build and maintain relationships with the vendors, consultants and contractors who will help with software development and maintenance.
  • You will communicate complex software and data concepts and results to both internal and external audiences, and will contribute to open-source and collaborative projects.

Your Navigation Tools:

  • Advanced degree (or equivalent experience) in computer science, software engineering, data science or other scientific field that has relevance to high-dimensional biological data (e.g., genetics, genomics, imaging).
  • Extensive experience in the use of a high-level programming language (particularly Python, R/Bioconductor or C/C++).
  • Experience applying best practices for devops; expertise in continuous integration/continuous deployment; building and deploying Docker and familiarity with Kubernetes; certification in (or equivalent experience with) AWS cloud services.
  • Familiarity with Illumina sequencing technologies (including alignment, variant calling and annotation methods) or other high-dimensional biological data.
  • A demonstrated ability to understand engineering needs from multiple functions and an eagerness to work in a fast-paced, highly matrixed environment; experience working and communicating with scientific teams; strong communication, data presentation and visualization skills.
  • A detail-oriented approach to projects, experience with troubleshooting and optimizing software systems and a demonstrated drive to raise the bar with every project
  • Some experience with data science, statistical modeling, and machine learning preferred.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Research Associate / Senior Research Associate, Cell Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking talented and highly motivated biologists to establish cell-based and biochemical assays to drive our early programs, contribute to the execution of genome-wide cell-based genetic and small molecule screens, and perform detailed mechanistic biology studies. Strong candidates will be highly organized, eager to learn and will have the self-confidence to work across boundaries to help answer challenging scientific questions.

Your Role in Navigating The Maze:

  • Design and perform in vitro studies and assays for target validation and in support of therapeutics development (product related characterization assays and preclinical assays -bioanalytical development).
  • You will proactively support development of assay strategies and engage with members of the team in experimental design, troubleshooting, sample analysis, data interpretation, and report generation.
  • Work well independently and in collaboration with colleagues across various functional areas.
  • Manage, process, analyze and present data
  • You will present data in group and project team meetings.

Your Navigation Tools:

  • B.S./M.S. in a biological science and at least 3-7 years (there is room for more senior positions) of lab experience in a biotechnology, pharmaceutical, or academic setting.
  • Ideal candidates will have a depth of research experience in cell biology and assay development and a broad range of additional laboratory skills.
  • Experience in a drug discovery environment is preferred but not required.
  • Experience and expertise with mammalian cell culture is required. Additional experience with cell line engineering is preferred, and experience working with and isolating primary cells is a plus.
  • Experience with development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA) is required. Experience with one or more of the following is preferred: flow cytometry, fluorescence microscopy, image-based high content assays, gene expression analysis, and laboratory automation.
  • Excellent data analysis skills and experience with a variety of scientific software applications is required.
  • Experience representing Pharmacology in cross-functional project teams
  • Excellent communication, presentation, collaboration, time-management, and organizational skills and are required.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Research Associate / Senior Research Associate, Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking talented and highly motivated individuals with expertise in molecular and cellular biology to join our functional genomics team. These individuals will catalyze our efforts to discover new therapeutic targets by developing and running cell-based CRISPR screens using a variety of assay technologies and contribute to development of new functional genomics screening technologies.

Your Role in Navigating The Maze:

  • Cell line engineering and assay development to enable functional genomic screening for new genetic modifier targets.
  • You will optimize, troubleshoot, and execute genome-wide lentiviral CRISPR screens with Next Gen Sequencing and other assay readouts.
  • Analysis of screen outputs and follow-up of hits with disease-relevant cell-based assays.
  • You will collaborate with colleagues on our therapeutic area teams to develop assay strategies for primary screens and hit validation assays.
  • Contribute to development of automated processes, data analysis methods, and advanced assay technologies including single cell RNA-seq assays and imaged-based high-content assays.

Your Navigation Tools:

  • BS/MS in a biological science discipline and at least 3-10 years of relevant experience.
  • Broad laboratory experience and skills in molecular and cell biology.
  • Expertise in mammalian cell culture is required, experience with cell line engineering, lentivirus transduction, and Next Gen Sequencing methodologies is preferred, and experience working with primary cells is a plus.
  • Expertise in cell-based assay development and screening using a variety of readout technologies including flow cytometry, image-based assays, reporter gene, and gene expression-based assays. Experience with large-scale CRISPR screens in pooled and/or arrayed formats is strongly desired.
  • Experience and comfort with laboratory automation is preferred, and high throughput screening experience is a plus.
  • Strong experimental design, troubleshooting, and data analysis skills.
  • Excellent communication, presentation, collaboration, and organizational skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Senior Scientist / Scientist, In Vitro Pharmacology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a highly qualified in vitro pharmacologist with extensive experience in biochemical and cell-based functional assays. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.

Your Role in Navigating The Maze:

  • Conduct and supervise in vitro studies to determine on-target and off-target potency and kinetics in biochemical, and cell or tissue-based functional assays across multiple projects
  • Lead assay development and automation activities
  • In vivo experience a bonus
  • Manage, process, analyze and present data
  • Assist with the coordination of studies with CROs as necessary

Your Navigation Tools:

  • MS/PhD in relevant field with 6+ years’ experience in pharmacology, molecular or cellular biology within a pharmaceutical or biotech company
  • Comprehensive working knowledge of biochemical/biomolecular assays and automation technologies
  • Experience with mammalian cell culture
  • Solid knowledge of screening, data analysis, and pharmacology concepts
  • Excellent communication skills and ability to work in a team-based environment
  • Detail oriented and highly organized
  • Experience representing Pharmacology in cross-functional project teams
  • Management/supervisory experience

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Senior / Principal Scientist Biomarker Development, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking exceptional, hands-on researchers with a strong background in disease characterization and biomarker technology to contribute to challenging projects in drug discovery and development that employ multiple therapeutic modalities to treat diseases in a variety of therapeutic areas (including neurologic disease, metabolic disease and renal disease). Our scientists work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics across Maze programs.

Your Role in Navigating The Maze:

  • You will develop the strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable data-driven decisions on program progression.
  • You will establish assays to evaluate PK/PD/efficacy relationships.
  • Initiate and manage external research collaborations to identify diagnostic and prognostic biomarkers for indications of interest.
  • You will participate in and lead cross-functional teams to support preclinical drug discovery and development.
  • Prepare, review and deliver high quality scientific presentations for internal/external use.

Your Navigation Tools:

  • PhD with at least 5 years post-degree research in an industry setting.
  • Hands on experience in the development and validation of biomarker assays in the preclinical and/or clinical setting.
  • Extensive experience with diverse biomarker assay technology platforms and proven assay troubleshooting skills.
  • Strong publication record and demonstrated experience conducting independent research.
  • Strong leadership skills and evidence of strategic scientific thinking.
  • Effective managerial skills and the ability to lead independent scientists with different backgrounds.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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The well-being of our employees and their families is important to us

We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.


Note to Recruitment Agencies: Please do not forward any agency resumes. Maze Therapeutics is not responsible for any fees related to resumes that are unsolicited.


Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.