Maze Therapeutics

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our people

At Maze, our number one focus is people – from the patients we work tirelessly to help to the families whose genetic modifiers inspire our therapies to the members of our team who embrace our mission.

Enter the maze

Our team is comprised of world class scientists and experienced company builders who have an unparalleled commitment to changing the way people with devastating diseases are treated.

We are always looking for talented and creative people to join us in our mission. Interested in working at Maze? Please email careers@mazetx.com

job openings

Senior Scientist / Scientist, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking an exceptional, hands-on researcher to contribute to challenging projects in drug discovery and target discovery for a variety of therapeutic areas (including metabolic disease, ophthalmic disease, cardiovascular and renal disease). We are modality agnostic and campaigns may include both small molecule and biologic therapeutics. Target discovery will require careful and creative design of next-generation screens to search for modifiers of disease. Successful candidates will contribute directly to the development of new target concepts and the design of novel disease-modifying therapeutics.

Your Role in Navigating The Maze:

  • You will work in close collaboration with human genetics and functional genomics to design and interpret studies for new target identification.
  • You will have the opportunity to lead interdisciplinary drug discovery project teams.
  • You will lead target validation efforts and design and implement assays for therapeutic discovery.
  • You will contribute to writing patents, reports and scientific publications.
  • You will manage and mentor junior research colleagues.

Your Navigation Tools:

  • PhD in a relevant field with >3 years post-PhD experience or BS/MS + >8 years experience.
  • 2 years of industry experience with a good understanding of drug discovery.
  • Hands-on experience with standard molecular and cellular biology techniques, biochemistry/chemical biology and proven technical expertise in compound screening (cell and biochemical assay formats).
  • Deep expertise in cell biology and expertise designing complex assays for new targets.
  • Prior experience managing research associates and leading projects is preferred/
  • Highly motivated to excel in a drug discovery environment that is highly collaborative and cross functional.
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Head of In Vitro Sciences

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking highly qualified in leader and in vitro scientist with extensive experience in
biochemical and cellular assays for target validation and in vitro pharmacology. The successful candidate will have expertise in biochemistry and/or enzymology and will be a primary lead as it relates to biochemical assay development and small molecule screening. Additional experience with cellular assays is important. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.

Your Role in Navigating The Maze:

  • Conduct and supervise in vitro studies to determine on-target and off-target activity in
    biochemical and/or cellular assays across multiple projects.
  • Lead assay development group and manage the application of automation and informatics activities to provide regular high quality assay results that help drive project team decision.
  • In vivo experience is a plus, as you will collaborate with in vivo for new studies.
  • Serve as the SME for biochemical assay development and enzymology; lead an in vitro sciences / assay development group over time.
  • Manage, process, analyze and present data.
  • Assist with the coordination of studies with CROs as necessary.

Your Navigation Tools:

  • PhD in relevant field with 8+ years’ experience with in vitro biochemical and cell-based assay development and screening to drive small molecule optimization programs.
  • Experience building and guiding teams to perform at their highest; experience working with cross functional teams to drive programs forward
  • Comprehensive working knowledge of biochemistry and small molecule screening.
  • Familiarity with new technologies, and an openness to their utilization.
  • Experience with mammalian cell culture.
  • Solid knowledge of automation applications for small molecule screening, data analysis, and pharmacology concepts.
  • Experience with biophysical assays a plus.
  • Experience representing in vitro assay development and screening in cross-functional project teams.
  • Detail oriented and highly organized.
  • Management/supervisory experience is required.
  • Level will be commensurate with experience.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Research Associate / Senior Research Associate, Medicinal Chemistry

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in organic, synthetic or medicinal chemistry to join our dynamic and highly-collaborative drug discovery team. The successful candidate will be responsible for the synthesis, purification, and characterization of novel, biologically-active small molecules. This is a hands-on role utilizing cutting-edge techniques and advanced technology to contribute to novel molecules for therapeutic use.

Your Role in Navigating The Maze:

  • Conduct multistep syntheses of complex small molecules supported with detailed characterization of intermediates and final products
  • Design and execute experiments and tasks in consultation with chemistry colleagues
  • Propose new compounds for synthesis based on synthetic knowledge and SAR
  • Summarize / interpret results and present findings in research meetings
  • Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are performed to a high standard
  • You will utilize scientific literature and databases such as SciFinder to design and implement efficient synthetic routes
  • Collaborate with scientists across functions to develop and optimize newly generated molecules

Your Navigation Tools:

  • BS/MS in Chemistry with at least 2 years of relevant laboratory experience in synthetic organic/medicinal chemistry
  • Industry experience is highly preferred; experience working across teams on projects is preferred
  • Demonstrated experience in multi-step organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, LCMS, HPLC, etc.)
  • Interest in medicinal chemistry concepts with an ability learn and adapt in a fast-moving environment
  • Organized and detail-oriented record-keeping skills, ability to multi-task, and excellent verbal and written communication skills
  • Demonstrated experience in conceptualizing chemistry experiments and performing techniques to execute

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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Data Scientist / Senior Data Scientist, Human Genetics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated scientist to help build and apply our genetics discovery platform. The successful candidate will join a team of data scientists, computational biologists, systems architects and automation engineers to mobilize genetics and functional genomics data towards the discovery of new therapeutic targets and drugs.

Your Role in Navigating The Maze:

  • Contribute to designing and building the data and computational ecosystem for the company’s R&D efforts
  • Responsible for managing and integrating human genetics data from public and proprietary sources
  • You will work with the Human Genetics department to implement production-quality, cutting-edge data management, analysis and visualization tools
  • Contribute to building production-quality, scalable bioinformatics and genetics pipelines
  • Build and maintain relationships with external collaborators to obtain and manage complex genetics data
  • Communicate data and scientific results to both internal and external audiences, and will contribute to open-source and collaborative projects

Your Navigation Tools:

  • Advanced degree (or equivalent experience) in human genetics, computational biology, bioinformatics or other scientific field that has relevance to high-dimensional biological data
  • Extensive familiarity with genotyping and sequencing technologies (including alignment, variant calling and annotation methods), and with pipelines for analyzing genotype and phenotype data (PLINK, HAIL)
  • Extensive experience in the use of a high-level programming language (particularly R/Bioconductor, Python/Pandas or C/C++)
  • Experience with large biobank resources (e.g., UK biobank) or data aggregators (e.g., Open Targets)
  • A demonstrated ability to understand scientific needs from multiple functions and an eagerness to work in a fast-paced, highly matrixed environment; experience working and communicating with scientific teams; strong communication, data presentation and visualization skills
  • A detail-oriented approach to projects, experience with troubleshooting and optimizing data and software systems and a demonstrated drive to raise the bar with every project
  • Experience with statistical modeling and machine learning a plus

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Download Job Description HereEmail

Head of Medicinal Chemistry

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a Head of Medicinal Chemistry that will build and lead a team of talented chemists to generate, optimize and develop lead small novel small molecules. You will collaborate with other cross functional leaders to create a strategy for drug discovery and deliver development candidates for our small molecule programs.

Your Role in Navigating The Maze:

  • You will apply your drug hunting expertise to leading teams and developing strategy across the spectrum of drug discovery, but we are counting on your expertise in early discovery, including planning a lead generation strategy and executing on hit assessment through optimization and development candidate selection. You will work closely and collaboratively in a multi-disciplinary team of computational chemists, biophysicists, cell and molecular biologists, pharmacologists, and DMPK specialists. You see how all the aspects of compound performance are necessary to make it a drug, and you can communicate that effectively to your discovery partners and lead the Medicinal Chemistry team to produce the desired results.
  • You will have responsibility for recruiting and supervising talented chemists as well as interactions with teams at CROs, and you take seriously your role as coach and mentor to your colleagues.
  • You will contribute to the chemistry team’s development of a platform for efficient project execution by identifying and establishing collaborations with both academic and industry partners to expand our capabilities. Internally, you will help drive the implementation of cutting-edge in silico methods of compound design and data analysis to facilitate rapid SAR decision making.
  • You will contribute to writing patents, reports and scientific publications.
  • You will partner with HR in leading recruiting for Med Chem, manage and mentor junior research colleagues.

Your Navigation Tools:

  • Ph.D. in chemistry with an emphasis on synthetic organic chemistry, synthetic methodology or a related field.
  • 10+ years of relevant biotech and/or pharmaceutical industry experience in medicinal chemistry.
  • Prior experience leading and participated in the delivery of development candidates from discovery into development, and your track record of excellence is supported by high impact, peer-reviewed publications and/or patents.
  • Strong experience with multiple, different target classes in programs that produced development candidates
  • Enthusiastic and excited to focus on lead generation and love the challenge of identifying the chemical matter that lays a foundation for a great project.
  • Experience and willingness to use silico predictive tools to enable your compound designs as well as structure-based drug design.
  • Highly motivated to excel in a drug discovery environment that is highly collaborative and cross functional.
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Download Job Description HereEmail

Senior Scientist / Scientist, In Vitro Pharmacology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a highly qualified in vitro pharmacologist with extensive experience in biochemical and cell-based functional assays. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.

Your Role in Navigating The Maze:

  • Conduct and supervise in vitro studies to determine on-target and off-target potency and kinetics in biochemical, and cell or tissue-based functional assays across multiple projects
  • Lead assay development and automation activities
  • In vivo experience a bonus
  • Manage, process, analyze and present data
  • Assist with the coordination of studies with CROs as necessary

Your Navigation Tools:

  • MS/PhD in relevant field with 6+ years’ experience in pharmacology, molecular or cellular biology within a pharmaceutical or biotech company
  • Comprehensive working knowledge of biochemical/biomolecular assays and automation technologies
  • Experience with mammalian cell culture
  • Solid knowledge of screening, data analysis, and pharmacology concepts
  • Excellent communication skills and ability to work in a team-based environment
  • Detail oriented and highly organized
  • Experience representing Pharmacology in cross-functional project teams
  • Management/supervisory experience

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Download Job Description HereEmail

Senior Research Associate, Protein Sciences / Biophysics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in Protein Sciences. Individuals will join a dynamic and highly-collaborative multidisciplinary team focused on discovery and advancement of new drug candidates. The primary responsibility of this position will be the expression, purification, and structural/biophysical characterization of proteins. The successful candidate will be of the Drug Discovery team and contribute to the discovery of new therapies through their work in protein science and production.

Your Role in Navigating The Maze:

  • You will conduct protein expression and purification experiments to support drug discovery programs.
  • You will perform hands-on protein crystallization trials and crystal harvesting.
  • Design and execute biophysical experiments to support drug discovery.
  • You will work with scientists to perform biophysical techniques and optimize protein production
  • Contribute to the generation of new experiments, techniques and collaborate with scientists on scientific literature
  • Summarize/interpret results and present findings in research meetings.

Your Navigation Tools:

  • B.S. or M.S. in a biological or chemical field with 3+ years of relevant experience in recombinant protein production and characterization. Industry experience is highly preferred.
  • Demonstrated experience in protein production (bacterial, insect and mammalian cells) and purification with modern chromatography techniques.
  • Experience in protein characterization with various biochemical and biophysical techniques (DSF, SPR, FP).
  • Experience working with diverse protein targets is a plus.
  • Working knowledge of protein crystallization (manual, robotics) and condition optimization for obtaining diffraction-quality protein crystals.
  • Highly motivated to excel in a drug discovery environment that is highly collaborative and cross functional.
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Ability to collaborate and work well in a team environment.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Download Job Description HereEmail

The well-being of our employees and their families is important to us

We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.


Note to Recruitment Agencies: Please do not forward any agency resumes. Maze Therapeutics is not responsible for any fees related to resumes that are unsolicited.


Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.