Maze Therapeutics

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our people

At Maze, our number one focus is people – from the patients we work tirelessly to help to the families whose genetic modifiers inspire our therapies to the members of our team who embrace our mission.

Enter the maze

Our team is comprised of world class scientists and experienced company builders who have an unparalleled commitment to changing the way people with devastating diseases are treated.

We are always looking for talented and creative people to join us in our mission. Interested in working at Maze? Please email careers@mazetx.com

job openings

Senior Scientist / Scientist, In Vitro Pharmacology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a highly qualified in vitro pharmacologist with extensive experience in biochemical and cell-based functional assays. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.

Your Role in Navigating The Maze:

  • Conduct and supervise in vitro studies to determine on-target and off-target potency and kinetics in biochemical, and cell or tissue-based functional assays across multiple projects
  • Lead assay development and automation activities
  • In vivo experience a bonus
  • Manage, process, analyze and present data
  • Assist with the coordination of studies with CROs as necessary

Your Navigation Tools:

  • MS/PhD in relevant field with 6+ years’ experience in pharmacology, molecular or cellular biology within a pharmaceutical or biotech company
  • Comprehensive working knowledge of biochemical/biomolecular assays and automation technologies
  • Experience with mammalian cell culture
  • Solid knowledge of screening, data analysis, and pharmacology concepts
  • Excellent communication skills and ability to work in a team-based environment
  • Detail oriented and highly organized
  • Experience representing Pharmacology in cross-functional project teams
  • Management/supervisory experience

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Senior Research Associate / Scientist, In Vivo Pharmacology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a qualified in vivo pharmacologist with experience in preclinical pharmacodynamic and disease models. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.​

Your Role in Navigating The Maze:

  • Conduct in vivo preclinical studies to demonstrate target engagement or efficacy in disease models to support drug candidate discovery
  • Assist in model development
  • Manage, process, analyze and present data
  • Assist with the coordination of studies with CROs

Your Navigation Tools:

  • BA/BS/MS in relevant field with 3+ years’ experience in pharmacology or related discipline within a pharmaceutical company
  • Broad expertise with in vivo preclinical pharmacodynamic or disease models
  • Experience with in vivo biological sample collection for pharmacokinetic analysis
  • Fluency with general biology lab procedures
  • Solid knowledge of pharmacology concepts
  • Excellent communication skills and ability to work in a team-based environment
  • Detail oriented and highly organized
  • Experience representing Pharmacology in cross-functional project teams
  • Level will be commensurate with experience

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist I / II, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking exceptional, hands-on researchers to contribute to challenging projects in drug discovery and target discovery for a variety of therapeutic areas (including neurologic disease, metabolic disease, renal disease, and oncology). Our scientists work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. We are modality agnostic and campaigns may include both small molecule and biologic therapeutics.

Your Role in Navigating The Maze:

  • You will design, develop and execute biochemical and cellular assays to profile novel therapeutics.
  • Design and conduct experiments to validate therapeutic concepts for target disease.
  • You will develop and execute pooled or arrayed functional genomics screens of cellular disease models, using cell lines or differentiated cells (e.g., stem cell-derived neurons).
  • You will analyze complex genomics or compound screening data sets.
  • Collaborate with internal and external members of cross-functional project teams.

Your Navigation Tools:

  • PhD in a relevant field, or BS/MS + >8 years’ experience in an academic or industrial setting. Level is commensurate with experience.
  • Specific experience is preferred in some of: cellular disease modeling, functional genomics, biochemical and cellular assay development.
  • Computational skills, such as R/Python scripting, or similar, are a plus.
  • The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to diverse projects and enjoy working in a fast-paced team environment.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Research Associate / Senior Research Associate, Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking talented and highly motivated individuals with expertise in molecular and cellular biology to join our functional genomics team. These individuals will catalyze our efforts to discover new therapeutic targets by developing and running cell-based CRISPR screens using a variety of assay technologies and contribute to development of new functional genomics screening technologies.

Your Role in Navigating The Maze:

  • Cell line engineering and assay development to enable functional genomic screening for new genetic modifier targets.
  • You will optimize, troubleshoot, and execute genome-wide lentiviral CRISPR screens with Next Gen Sequencing and other assay readouts.
  • Analysis of screen outputs and follow-up of hits with disease-relevant cell-based assays.
  • You will collaborate with colleagues on our therapeutic area teams to develop assay strategies for primary screens and hit validation assays.
  • Contribute to development of automated processes, data analysis methods, and advanced assay technologies including single cell RNA-seq assays and imaged-based high-content assays.

Your Navigation Tools:

  • BS/MS in a biological science discipline and at least 3-10 years of relevant experience.
  • Broad laboratory experience and skills in molecular and cell biology.
  • Expertise in mammalian cell culture is required, experience with cell line engineering, lentivirus transduction, and Next Gen Sequencing methodologies is preferred, and experience working with primary cells is a plus.
  • Expertise in cell-based assay development and screening using a variety of readout technologies including flow cytometry, image-based assays, reporter gene, and gene expression-based assays. Experience with large-scale CRISPR screens in pooled and/or arrayed formats is strongly desired.
  • Experience and comfort with laboratory automation is preferred, and high throughput screening experience is a plus.
  • Strong experimental design, troubleshooting, and data analysis skills.
  • Excellent communication, presentation, collaboration, and organizational skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist, Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking innovative scientists to build Maze’s functional genomics platforms and utilize them to discover new genetic modifier targets for our therapeutic programs. These individuals will have expertise in one or more of the following: molecular and cellular biology including cell engineering, cell-based assay development including assays and technologies for CRISPR screens, and development of new molecular biology tools and screening technologies.

Your Role in Navigating The Maze:

  • You will develop and integrate technologies for genome-wide CRISPR screens into a world-class platform and continue to look for opportunities to improve our capabilities.
  • Engineer cell lines and develop assays and model systems for functional genomics screens for new genetic modifier targets.
  • You will develop, run, and analyze functional genomics screens.
  • Develop strategies for hit follow-up and target validation in collaboration with colleagues from our human genetics and therapeutic area teams.
  • Optimization of screening workflows using automation and analysis pipelines in collaboration with colleagues from our research infrastructure and data science teams.
  • Champion ideas for new target discovery projects.
  • Mentor junior members of the Functional Genomics team.

Your Navigation Tools:

  • PhD with at least 3-8 years of relevant experience in a pharmaceutical, biotechnology, or academic setting or a MS with several years of relevant industry experience.
  • An outstanding reputation in your field as a creative scientist and technology innovator.
  • Broad laboratory experience and skills in molecular and cell biology. Experience with several of the following: CRISPR screening in pooled and/or arrayed formats, cell line engineering, Next Gen Sequencing, CRISPRa/CRISPRi, single cell RNA-seq.
  • Extensive experience with cell-based assay development and screening using a variety of readout technologies including flow cytometry, image-based assays, reporter gene, and gene expression-based assays.
  • Strong quantitative intuition, excellent data analysis and data mining skills, and experience and comfort with laboratory automation.
  • Outstanding communication, collaboration, and project management skills.
  • Track record of mentoring and developing associates is a plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Research Associate, DMPK, Drug Discovery

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a highly qualified bioanalytical Research Associate with extensive experience using LC-MS for measurement of small molecule concentrations in various matrices (i.e. blood, plasma, tissues, etc.). The ideal candidate will be familiar with various sample extraction techniques, such as liquid-liquid extraction and SPE, and should be able to perform routine LC-MS method development, maintenance and troubleshooting. Experience with high resolution mass spectrometers (Q-Exactive) and Phoenix WinNonlin software is a plus.

Your Role in Navigating The Maze:

  • You will develop LC-MS methods for the analysis of small molecules.
  • Prepare and analyze PK samples; process data and write PK/TK reports.
  • You will perform routine LC-MS maintenance.
  • You will conduct in vitro studies to determine metabolic stability, protein binding, etc.
  • Coordinate with CROs for scheduling of studies and shipment of samples.

Your Navigation Tools:

  • BA/BS/MS in relevant field with 3+ years’ experience in DMPK within a pharmaceutical company.
  • A minimum of 1 year of experience with LC-MS operation.
  • Solid knowledge of PK parameters and general DMPK concepts.
  • Excellent communication skills and ability to work in a team-based environment is essential.
  • Experience representing DMPK in cross-functional project teams is a major plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Research Associate / Senior Research Associate, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking talented and highly motivated biologists to establish cell-based and biochemical assays to drive our early programs, contribute to the execution of genome-wide cell-based genetic and small molecule screens, and perform detailed mechanistic biology studies. Strong candidates will be highly organized, eager to learn and will have the self-confidence to work across boundaries to help answer challenging scientific questions.

Your Role in Navigating The Maze:

  • Design and perform in vitro studies and assays for target validation and in support of therapeutics development (product related characterization assays and preclinical assays -bioanalytical development).
  • You will proactively support development of assay strategies and engage with members of the team in experimental design, troubleshooting, sample analysis, data interpretation, and report generation.
  • Work well independently and in collaboration with colleagues across various functional areas.
  • You will present data in group and project team meetings.

Your Navigation Tools:

  • B.S./M.S. in a biological science and at least 3-7 years (there is room for more senior positions) of lab experience in a biotechnology, pharmaceutical, or academic setting.
  • Ideal candidates will have a depth of research experience in cell biology and assay development and a broad range of additional laboratory skills.
  • Experience in a drug discovery environment is preferred but not required.
  • Experience and expertise with mammalian cell culture is required. Additional experience with cell line engineering is preferred, and experience working with and isolating primary cells is a plus.
  • Experience with development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA) is required. Experience with one or more of the following is preferred: flow cytometry, fluorescence microscopy, image-based high content assays, gene expression analysis, and laboratory automation.
  • Excellent data analysis skills and experience with a variety of scientific software applications is required.
  • Excellent communication, presentation, collaboration, time-management, and organizational skills and are required.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Senior / Principal Scientist Biomarker Development, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking exceptional, hands-on researchers with a strong background in disease characterization and biomarker technology to contribute to challenging projects in drug discovery and development that employ multiple therapeutic modalities to treat diseases in a variety of therapeutic areas (including neurologic disease, metabolic disease and renal disease). Our scientists work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics across Maze programs.

Your Role in Navigating The Maze:

  • You will develop the strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable data-driven decisions on program progression.
  • You will establish assays to evaluate PK/PD/efficacy relationships.
  • Initiate and manage external research collaborations to identify diagnostic and prognostic biomarkers for indications of interest.
  • You will participate in and lead cross-functional teams to support preclinical drug discovery and development.
  • Prepare, review and deliver high quality scientific presentations for internal/external use.

Your Navigation Tools:

  • PhD with at least 5 years post-degree research in an industry setting.
  • Hands on experience in the development and validation of biomarker assays in the preclinical and/or clinical setting.
  • Extensive experience with diverse biomarker assay technology platforms and proven assay troubleshooting skills.
  • Strong publication record and demonstrated experience conducting independent research.
  • Strong leadership skills and evidence of strategic scientific thinking.
  • Effective managerial skills and the ability to lead independent scientists with different backgrounds.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist In Vivo Tumor, Immunology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in Immunology to join our dynamic and highly-collaborative research team. The successful candidate will evaluate new immunotherapy modalities to treat cancer.

Your Role in Navigating The Maze:

  • You will conceptualize, develop and implement robust in vitro assays and in vivo tumor models in both xenogeneic and syngeneic settings.
  • Select, plan and execute efficacy / MOA / biodistribution studies and provide effective and timely data analysis and interpretation in support of preclinical immuno-oncology programs.
  • You will champion in vivo immunology and tumor biology efforts into new directions to achieve critical project milestones.
  • You will participate in cross-functional teams and interact with chemists, biologists and external collaborators to advance drug discovery programs.
  • Contribute effectively to patent, report and scientific publication writing.
  • You will manage junior immunology research colleagues.

Your Navigation Tools:

  • PhD in immunology, tumor biology or a related field with ≥3 years post-PhD experience.
  • Industry experience is a plus.
  • Hands-on experience in molecular and cellular biology, cell culture, flow cytometry, T cell functional assays and experience with mouse models.
  • The optimal candidate will have a strong and up-to-date command of MHC biology, antigen presentation, T-cell immunology and/or tumor biology.
  • Project and CRO management experience are a plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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The well-being of our employees and their families is important to us

We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.


Note to Recruitment Agencies: Please do not forward any agency resumes. Maze Therapeutics is not responsible for any fees related to resumes that are unsolicited.


Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.