Maze Therapeutics

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our people

At Maze, our number one focus is people – from the patients we work tirelessly to help to the families whose genetic modifiers inspire our therapies to the members of our team who embrace our mission.

Enter the maze

Our team is comprised of world class scientists and experienced company builders who have an unparalleled commitment to changing the way people with devastating diseases are treated.

We are always looking for talented and creative people to join us in our mission. Interested in working at Maze? Please email careers@mazetx.com

job openings

Research Associate / Senior Research Associate, Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking talented and highly motivated individuals with expertise in molecular and cellular biology to join our functional genomics team. These individuals will catalyze our efforts to discover new therapeutic targets by developing and running cell-based CRISPR screens using a variety of assay technologies and contribute to development of new functional genomics screening technologies.

Your Role in Navigating The Maze:

  • Cell line engineering and assay development to enable functional genomic screening for new genetic modifier targets.
  • You will optimize, troubleshoot, and execute genome-wide lentiviral CRISPR screens with Next Gen Sequencing and other assay readouts.
  • Analysis of screen outputs and follow-up of hits with disease-relevant cell-based assays.
  • You will collaborate with colleagues on our therapeutic area teams to develop assay strategies for primary screens and hit validation assays.
  • Contribute to development of automated processes, data analysis methods, and advanced assay technologies including single cell RNA-seq assays and imaged-based high-content assays.

Your Navigation Tools:

  • BS/MS in a biological science discipline and at least 3-10 years of relevant experience.
  • Broad laboratory experience and skills in molecular and cell biology.
  • Expertise in mammalian cell culture is required, experience with cell line engineering, lentivirus transduction, and Next Gen Sequencing methodologies is preferred, and experience working with primary cells is a plus.
  • Expertise in cell-based assay development and screening using a variety of readout technologies including flow cytometry, image-based assays, reporter gene, and gene expression-based assays. Experience with large-scale CRISPR screens in pooled and/or arrayed formats is strongly desired.
  • Experience and comfort with laboratory automation is preferred, and high throughput screening experience is a plus.
  • Strong experimental design, troubleshooting, and data analysis skills.
  • Excellent communication, presentation, collaboration, and organizational skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist, Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking innovative scientists to build Maze’s functional genomics platforms and utilize them to discover new genetic modifier targets for our therapeutic programs. These individuals will have expertise in one or more of the following: molecular and cellular biology including cell engineering, cell-based assay development including assays and technologies for CRISPR screens, and development of new molecular biology tools and screening technologies.

Your Role in Navigating The Maze:

  • You will develop and integrate technologies for genome-wide CRISPR screens into a world-class platform and continue to look for opportunities to improve our capabilities.
  • Engineer cell lines and develop assays and model systems for functional genomics screens for new genetic modifier targets.
  • You will develop, run, and analyze functional genomics screens.
  • Develop strategies for hit follow-up and target validation in collaboration with colleagues from our human genetics and therapeutic area teams.
  • Optimization of screening workflows using automation and analysis pipelines in collaboration with colleagues from our research infrastructure and data science teams.
  • Champion ideas for new target discovery projects.
  • Mentor junior members of the Functional Genomics team.

Your Navigation Tools:

  • PhD with at least 3-8 years of relevant experience in a pharmaceutical, biotechnology, or academic setting or a MS with several years of relevant industry experience.
  • An outstanding reputation in your field as a creative scientist and technology innovator.
  • Broad laboratory experience and skills in molecular and cell biology. Experience with several of the following: CRISPR screening in pooled and/or arrayed formats, cell line engineering, Next Gen Sequencing, CRISPRa/CRISPRi, single cell RNA-seq.
  • Extensive experience with cell-based assay development and screening using a variety of readout technologies including flow cytometry, image-based assays, reporter gene, and gene expression-based assays.
  • Strong quantitative intuition, excellent data analysis and data mining skills, and experience and comfort with laboratory automation.
  • Outstanding communication, collaboration, and project management skills.
  • Track record of mentoring and developing associates is a plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Head of Functional Genomics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a dynamic and innovative scientist to build and lead Maze’s Functional Genomics Department with responsibility for discovery of new therapeutic targets and the development of world-class target discovery platforms, including a large-scale CRISPR screening platform. This individual will be responsible for assembling and leading a team with expertise spanning molecular biology, cell biology, cell engineering, assay development, screening operations, automation, data analysis, and new technology development.

Your Role in Navigating The Maze:

  • You will build a world-class functional genomics team by recruiting top talent, integrating cutting-edge technologies, and establishing lab operations.
  • Collaborate with our biology and therapeutic area teams to develop assay and screening strategies, model systems, and target validation strategies to identify new genetic modifier targets.
  • You will collaborate with our human genetics, data science, and research infrastructure teams to develop new technology platforms, including genome-wide CRISPR screening platforms and single cell assay technologies.
  • You will be responsible for delivering targets for new drug discovery programs and collaborating with leaders across the research organization to advance the programs.
  • You will be a champion of ideas for new target discovery projects.
  • Lead and mentor a team of scientists and technology developers.

Your Navigation Tools:

  • PhD in a biological discipline with at least 8-10 years of relevant experience in an industry (preferred) or academic setting.
  • An outstanding reputation in your field as a creative scientist, a technology innovator, and as a dynamic leader.
  • Deep expertise in cell and molecular biology and experience with state-of-the-art functional genomics screening technologies including contemporary expertise with CRISPR technologies used for genome-wide screens.
  • Extensive experience with cell-based assay development and screening using a variety of readout technologies.
  • Strong quantitative intuition, excellent data analysis and data mining skills, and experience and comfort with laboratory automation.
  • Direct supervisory experience (5+ years) leading a team of scientists (including PhD-level scientists) and a track record of recruiting, mentoring, and developing top talent.
  • Outstanding communication, collaboration, networking, and project leadership skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist, Bioinformatics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated Bioinformatics Scientist to help drive research programs across all of our therapeutic areas. The successful candidate will contribute as part of a team to build, deploy and apply computational methods to high-dimensional biological data sources (including human genetics and genome-scale data from functional screens).

Your Role in Navigating The Maze:

  • You will contribute to a team of computational biologists supporting target discovery and drug development programs.
  • You will contribute to the scientific and clinical strategy of the company, including the discovery of new targets.
  • Develop and pursue an independent research program that advances the company’s scientific mission.
  • Help implement tools and pipelines that ensure the scientific rigor of data collection, management and analysis; help develop the company’s target discovery platform.
  • You will communicate complex scientific concepts and results.

Your Navigation Tools:

  • PhD in bioinformatics, biostatistics, computational biology, genetics or similar biological field, with 2 years’ experience and a strong publication record.
  • Extensive experience in developing and/or applying computational methods to genome-scale data, following best practices of data stewardship and analytical reproducibility.
  • Extensive experience in the use of a high-level programming language (i.e., R or Python) and relevant bioinformatics packages (e.g., from Bioconductor) for complex data analysis.
  • Experience supporting and collaborating with non-computational biologists and training them in the use of self-service tools and analytics.
  • Strong communication, data presentation and visualization skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Senior Scientist / Principal Scientist, Bioinformatics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated senior-level Bioinformatics Scientist to help drive research programs across all of our therapeutic areas. The successful candidate will provide scientific and technical leadership, helping develop a team of computational biologists to build, deploy and apply computational methods to high-dimensional biological data sources (including human genetics and genome-scale data from functional screens).

Your Role in Navigating The Maze:

  • You will help build and lead a team of computational biologists to support target discovery and drug development programs.
  • You will contribute to the scientific and clinical strategy of the company, including the discovery of new targets.
  • Develop and pursue an independent research program that advances the company’s scientific mission.
  • You will help implement tools and pipelines that ensure the scientific rigor of data collection, management and analysis; you will help develop the company’s target discovery platform.
  • Communicate complex scientific concepts and results to scientists, collaborators and leadership.

Your Navigation Tools:

  • PhD in bioinformatics, biostatistics, computational biology, genetics or similar biological field, with a minimum of 5 years’ experience and a strong publication record.
  • Extensive experience in developing and/or applying computational methods to genome-scale data, following best practices of data stewardship and analytical reproducibility.
  • Extensive experience in the use of a high-level programming language (i.e., R or Python) and relevant bioinformatics packages (e.g., from Bioconductor) for complex data analysis.
  • Experience supporting and collaborating with non-computational biologists, and training them in the use of self-service tools and analytics.
  • Experience directing scientists and guiding their scientific and professional development.
  • Strong communication, data presentation and visualization skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Data Scientist / Data Engineer, Bioinformatics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated senior-level Data Scientist or Data Engineer to help lead in the development of our discovery platform. The successful candidate will join a team of computational biologists and systems architects to mobilize genetics and functional genomics data towards the discovery of new therapeutic targets and drugs.

Your Role in Navigating The Maze:

  • You will work with subject-matter experts to evaluate their data science needs and propose robust solutions.
  • Implement methods for execution of high-throughput assays and subsequent acquisition, management and analysis of the data.
  • You will design, deploy and maintain robust methods for data management and analysis, primarily using the AWS cloud environment.
  • Develop computational methods for integrating multiple high-dimensional data sources to facilitate target and drug discovery.
  • Provide computational tools to ensure trustworthy data sources and facilitate reproducible analysis.
  • You will communicate complex scientific, software and data concepts and results.

Your Navigation Tools:

  • Advanced degree (or equivalent experience of 2 years) in computer science, data science or a scientific field that has relevance to high-dimensional biological data (e.g., genetic, genomic, imaging).
  • Extensive experience in the use of a high-level programming language (i.e., R, Python or C/C++) and relevant bioinformatics and data science packages (e.g., Pandas, Numpy, Bioconductor) for complex data analysis.
  • Certification in (or equivalent experience with) AWS cloud services.
  • Experience working and communicating with scientific teams.
  • Strong communication, data presentation and visualization skills.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist, Computational Biology, Genetics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking an exceptional computational biologist/statistical geneticist to join our organization. The successful candidate will lead human genetic modifier screens utilizing genome-wide association techniques including correcting for population stratification, single variant and gene burden association methods, and polygenic scores.

Your Role in Navigating The Maze:

  • You will lead analyses of large-scale public human genetics datasets (UKBioBank, etc.) to identify genetic modifiers of disease.
  • Coordinate with external collaborators and work as part of a cross-functional team.
  • Integrate multiple data sources and develop tools to identify and validate candidate therapeutic targets.
  • You will contribute directly to the development of novel disease modifying therapeutics.

Your Navigation Tools:

  • Ph.D. or Master’s degree with significant relevant experience in bioinformatics / computational biology and the biologic interpretation of human genetic data.
  • Candidates with a B.S. in computer science with 3+ years applied experience in genetics research will also be considered.
  • Proficient in the management and analysis of large datasets, including those derived from SNP arrays and next-generation sequencing platforms, is ideal.
  • Experience in the analysis of large-scale genomic association studies in complex genetic diseases including correcting for population stratification and imputation of genotypes, a solid understanding of software development (Perl, Python), and a strong computational/statistical background (R) is highly desirable.
  • Experience with causality inference approaches (co-localization or mendelian randomization) to link functional variants in the human genome to association signals or analysis of CRISPR screens is a plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Senior Scientist, Computational Biology, Genetics

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a computational biologist/statistical geneticist to join our organization. The successful candidate will contribute to the design of robust genetic association and gene interaction studies, develop workflows/pipelines for association analyses and other statistical genetics techniques, and perform analyses on large-scale genetic datasets. In addition, the candidate will integrate results from functional genomics screens with human genetics and contribute to interpretation of results with the goal of identifying new therapeutic targets.

Your Role in Navigating The Maze:

  • You will lead analyses of large-scale public human genetics datasets (UKBioBank, etc.) to identify genetic modifiers of disease.
  • Integrate multiple data sources and develop tools to identify and validate candidate therapeutic targets.
  • You will work as part of a diverse cross-functional team at Maze.
  • Contribute directly to the development of novel disease modifying therapeutics.

Your Navigation Tools:

  • Ph.D. or a Master’s degree with significant relevant experience in bioinformatics / computational biology and the biologic interpretation of human genetic data.
  • Candidates with a B.S. in computer science with 5+ years applied experience in genetics research will also be considered.
  • Proficiency in the management and analysis of large datasets, including those derived from SNP arrays and next-generation sequencing platforms, is ideal.
  • Ability to analyze large-scale genomic association studies in complex genetic diseases including correcting for population stratification and imputation of genotypes, solidly understand software development (Perl, Python), and to possess a strong computational/statistical background (R) is highly desirable.
  • Experience with expression quantitative trait loci (eQTL) datasets and other approaches to identify functional variants, causality inference approaches (co-localization or mendelian randomization) to link functional variants in the human genome to association signals, or CRISPR screen analysis is a plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Research Associate / Senior Research Associate, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking talented and highly motivated biologists to establish cell-based and biochemical assays to drive our early programs, contribute to the execution of genome-wide cell-based genetic and small molecule screens, and perform detailed mechanistic biology studies. Strong candidates will be highly organized, eager to learn and will have the self-confidence to work across boundaries to help answer challenging scientific questions.

Your Role in Navigating The Maze:

  • Design and perform in vitro studies and assays for target validation and in support of therapeutics development (product related characterization assays and preclinical assays -bioanalytical development).
  • You will proactively support development of assay strategies and engage with members of the team in experimental design, troubleshooting, sample analysis, data interpretation, and report generation.
  • Work well independently and in collaboration with colleagues across various functional areas.
  • You will present data in group and project team meetings.

Your Navigation Tools:

  • B.S./M.S. in a biological science and at least 3-7 years (there is room for more senior positions) of lab experience in a biotechnology, pharmaceutical, or academic setting.
  • Ideal candidates will have a depth of research experience in cell biology and assay development and a broad range of additional laboratory skills.
  • Experience in a drug discovery environment is preferred but not required.
  • Experience and expertise with mammalian cell culture is required. Additional experience with cell line engineering is preferred, and experience working with and isolating primary cells is a plus.
  • Experience with development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA) is required. Experience with one or more of the following is preferred: flow cytometry, fluorescence microscopy, image-based high content assays, gene expression analysis, and laboratory automation.
  • Excellent data analysis skills and experience with a variety of scientific software applications is required.
  • Excellent communication, presentation, collaboration, time-management, and organizational skills and are required.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist I / II, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking exceptional, hands-on researchers to contribute to challenging projects in drug discovery and target discovery for a variety of therapeutic areas (including neurologic disease, metabolic disease, renal disease, and oncology). Our scientists work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. We are modality agnostic and campaigns may include both small molecule and biologic therapeutics.

Your Role in Navigating The Maze:

  • You will design, develop and execute biochemical and cellular assays to profile novel therapeutics.
  • Design and conduct experiments to validate therapeutic concepts for target disease.
  • You will develop and execute pooled or arrayed functional genomics screens of cellular disease models, using cell lines or differentiated cells (e.g., stem cell-derived neurons).
  • You will analyze complex genomics or compound screening data sets.
  • Collaborate with internal and external members of cross-functional project teams.

Your Navigation Tools:

  • PhD in a relevant field, or BS/MS + >8 years’ experience in an academic or industrial setting. Level is commensurate with experience.
  • Specific experience is preferred in some of: cellular disease modeling, functional genomics, biochemical and cellular assay development.
  • Computational skills, such as R/Python scripting, or similar, are a plus.
  • The successful candidate will be an ambitious self-starter, be motivated to apply his/her skills to diverse projects and enjoy working in a fast-paced team environment.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Senior / Principal Scientist Biomarker Development, Biology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking exceptional, hands-on researchers with a strong background in disease characterization and biomarker technology to contribute to challenging projects in drug discovery and development that employ multiple therapeutic modalities to treat diseases in a variety of therapeutic areas (including neurologic disease, metabolic disease and renal disease). Our scientists work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics across Maze programs.

Your Role in Navigating The Maze:

  • You will develop the strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable data-driven decisions on program progression.
  • You will establish assays to evaluate PK/PD/efficacy relationships.
  • Initiate and manage external research collaborations to identify diagnostic and prognostic biomarkers for indications of interest.
  • You will participate in and lead cross-functional teams to support preclinical drug discovery and development.
  • Prepare, review and deliver high quality scientific presentations for internal/external use.

Your Navigation Tools:

  • PhD with at least 5 years post-degree research in an industry setting.
  • Hands on experience in the development and validation of biomarker assays in the preclinical and/or clinical setting.
  • Extensive experience with diverse biomarker assay technology platforms and proven assay troubleshooting skills.
  • Strong publication record and demonstrated experience conducting independent research.
  • Strong leadership skills and evidence of strategic scientific thinking.
  • Effective managerial skills and the ability to lead independent scientists with different backgrounds.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist In Vivo Tumor, Immunology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in Immunology to join our dynamic and highly-collaborative research team. The successful candidate will evaluate new immunotherapy modalities to treat cancer.

Your Role in Navigating The Maze:

  • You will conceptualize, develop and implement robust in vitro assays and in vivo tumor models in both xenogeneic and syngeneic settings.
  • Select, plan and execute efficacy / MOA / biodistribution studies and provide effective and timely data analysis and interpretation in support of preclinical immuno-oncology programs.
  • You will champion in vivo immunology and tumor biology efforts into new directions to achieve critical project milestones.
  • You will participate in cross-functional teams and interact with chemists, biologists and external collaborators to advance drug discovery programs.
  • Contribute effectively to patent, report and scientific publication writing.
  • You will manage junior immunology research colleagues.

Your Navigation Tools:

  • PhD in immunology, tumor biology or a related field with ≥3 years post-PhD experience.
  • Industry experience is a plus.
  • Hands-on experience in molecular and cellular biology, cell culture, flow cytometry, T cell functional assays and experience with mouse models.
  • The optimal candidate will have a strong and up-to-date command of MHC biology, antigen presentation, T-cell immunology and/or tumor biology.
  • Project and CRO management experience are a plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist Assay Development, Immunology

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in MHC biology and antigen presentation, T-cell immunology and tumor biology to join our dynamic and highly-collaborative immunology team. The successful candidate will be responsible for assay development and implementation in the field of MHC-restricted antigen processing, presentation and T cell recognition.

Your Role in Navigating The Maze:

  • You will select and implement robust biochemical and in vitro cell-based assays, and independently perform low/medium throughput screening efforts to discover novel compounds with desirable function and activity.
  • Lead efforts to understand the mechanism of action and potency of novel compounds that impact MHC-restricted antigen-presentation, and the resulting T cell response.
  • Provide effective data analysis and interpretation in support of preclinical immuno-oncology programs and apply active follow-through to achieve critical project milestones.
  • You will work cooperatively within a multidisciplinary team to guide strategy, advance drug discovery programs, and proactively incorporate novel ideas.
  • You will contribute effectively to patent, report and scientific publication writing.
  • Manage junior immunology research colleagues.

Your Navigation Tools:

  • PhD in immunology, tumor biology or a related field with >3 years post-PhD experience.
  • 2 years of industry experience is considered a plus.
  • Strong background in MHC biology and antigen presentation, T-cell immunology and/or oncology/tumor biology combined with a good command of the current literature.
  • Hands-on experience with standard molecular and cellular biology techniques, cell culture, ELISA, ELISpot, flow cytometry, T-cell functional assays, and proven technical expertise in compound screening (cell and biochemical assay formats).

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist / Senior Scientist, Medicinal Chemistry

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in synthetic organic chemistry to join our dynamic and highly-collaborative medicinal chemistry team in the pursuit of novel small molecules to treat a diverse range of diseases. The successful candidate will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy, evaluate HTS data to identify promising hit compounds for follow up, collaborate effectively with team members across disciplines, present project results and strategy in key company meetings, and oversee the work of internal and external chemists.

Your Role in Navigating The Maze:

  • You will plan and execute the synthesis, purification, and characterization of complex small molecules.
  • Design novel chemical entities in alignment with project goals.
  • Integrate and utilize modern medicinal chemistry principles and tools.
  • You will advance drug discovery programs by interacting with other chemists, biologists and external collaborators to understand and optimize DMPK and in vitro and in vivo pharmacological properties.
  • Contribute effectively to patent, report and scientific publication writing.
  • You will employ sound judgment in the evaluation and strategic decision making around HTS screening data or literature hits.
  • You will effectively manage junior medicinal chemistry research colleagues and outsourced chemists.

Your Navigation Tools:

  • PhD. in synthetic organic chemistry or equivalent discipline.
  • More than 3 years industry experience.
  • Experience taking a program from initial hit to clinical candidate strongly preferred.
  • Excellent scientific expertise in organic synthesis and medicinal chemistry, conversant with the current literature.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Senior Research Associate, Medicinal Chemistry

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in Medicinal Chemistry to join our dynamic and highly-collaborative drug discovery team. The successful candidate will be responsible for the synthesis, purification, and characterization of novel, biologically-active small molecules.

Your Role in Navigating The Maze:

  • You will conduct multistep syntheses of complex small molecules supported with detailed characterization of intermediates and final products.
  • Design and execute experiments and tasks in consultation with chemistry colleagues.
  • You will propose new compounds for synthesis based on synthetic knowledge and SAR.
  • You will evaluate and clearly report experimental results to supervisors and colleagues on a routine basis with special attention to data quality and reproducibility.
  • Summarize / interpret results and present findings in research meetings.
  • Learn new laboratory techniques, troubleshoot experiments, and ensure experiments are performed to a high standard.
  • You will utilize scientific literature and databases such as SciFinder to design and implement efficient synthetic routes.
  • Contribute to exploratory research and collaborate closely with colleagues in other groups.

Your Navigation Tools:

  • BS/MS in Chemistry with >5 years of relevant experience in synthetic organic/medicinal chemistry with potential to learn and adapt in a fast-moving environment.
  • Demonstrated experience in organic synthesis, chromatographic purification methods, and compound characterization using modern analytical techniques (NMR, LCMS, HPLC, etc.).
  • Understanding of medicinal chemistry concepts.
  • Organized and detail-oriented record-keeping skills, excellent verbal and written communication skills.
  • Ability to both work independently and perform well in a team environment.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Research Associate, DMPK, Drug Discovery

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a highly qualified bioanalytical Research Associate with extensive experience using LC-MS for measurement of small molecule concentrations in various matrices (i.e. blood, plasma, tissues, etc.). The ideal candidate will be familiar with various sample extraction techniques, such as liquid-liquid extraction and SPE, and should be able to perform routine LC-MS method development, maintenance and troubleshooting. Experience with high resolution mass spectrometers (Q-Exactive) and Phoenix WinNonlin software is a plus.

Your Role in Navigating The Maze:

  • You will develop LC-MS methods for the analysis of small molecules.
  • Prepare and analyze PK samples; process data and write PK/TK reports.
  • You will perform routine LC-MS maintenance.
  • You will conduct in vitro studies to determine metabolic stability, protein binding, etc.
  • Coordinate with CROs for scheduling of studies and shipment of samples.

Your Navigation Tools:

  • BA/BS/MS in relevant field with 3+ years’ experience in DMPK within a pharmaceutical company.
  • A minimum of 1 year of experience with LC-MS operation.
  • Solid knowledge of PK parameters and general DMPK concepts.
  • Excellent communication skills and ability to work in a team-based environment is essential.
  • Experience representing DMPK in cross-functional project teams is a major plus.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Scientist I/II, Protein Sciences, Drug Discovery

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with a strong background in Protein Sciences. Individuals will join a dynamic and highly-collaborative multidisciplinary team focused on discovery and advancement of new drug candidates. The primary responsibility of this position will be the expression, purification, and structural/biophysical characterization of proteins. The successful candidate will work under the direct supervision of a Senior Scientist.

Your Role in Navigating The Maze:

  • You will conduct protein expression and purification experiments to support drug discovery programs.
  • You will perform hands-on protein crystallization trials and crystal harvesting.
  • Design and execute biophysical experiments to support drug discovery.
  • You will work cooperatively within a multidisciplinary team to guide strategy, advance drug discovery programs, and proactively incorporate novel ideas.
  • Contribute effectively to patent, report and scientific publication writing.
  • Summarize/interpret results and present findings in research meetings.

Your Navigation Tools:

  • Ph.D. in Biochemistry/Structural Biology with >2 years of relevant experience in recombinant protein production and characterization.
  • Demonstrated experience in protein production (bacterial, insect and mammalian cells) and purification with modern chromatography techniques.
  • Experience in protein characterization with various biochemical and biophysical techniques (DSF, SPR, SEC-MALS).
  • Working knowledge of protein crystallization (manual, robotics) and condition optimization for obtaining diffraction-quality protein crystals.
  • Organized, detail-oriented, excellent record-keeping skills, excellent verbal and written communication skills.
  • Ability to work independently and perform well in a team environment.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Vice President, Human Resources

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual to lead and execute all HR related activities for the company. The ideal candidate will be a creative, collaborative, results-oriented leader who has a passion for hiring the best talent, implementing creative reward and recognition programs, developing internal capabilities, and nurturing a culture of exceptional science, inclusivity and fun. The VP of HR will be an excellent strategist who is also able to execute the HR objectives in a growing organization.

Your Role in Navigating The Maze:

  • You will build the HR infrastructure needed to support the company’s growth and provide tactical support to help the business run effectively.
  • Develop effective and efficient approaches for recruiting to quickly hire the capabilities needed to achieve our mission.
  • Lead the development and execution of a total reward (compensation and benefits) strategy that enables the company to attract, hire, develop, and retain top talent.
  • Possess strong leadership and business acumen and relationship-building capabilities to inspire employees and the organization around common goals, vision and values.
  • You’ll engage with the all levels of the organization to establish an environment that is motivating and entrepreneurial in nature. Lead and coach the HR and executive teams to achieve a “best place to work” culture.
  • Promote a culture of innovation, collaboration, commitment, focus, excellence, and impact.

Your Navigation Tools:

  • An HR leader with 12+ years experience as a strong generalist/business partner with current knowledge of emerging HR trends and practices.
  • Experience in building a recruiting function, implementing performance management solutions and developing total reward strategies.
  • Ideal candidates will have helped support a new emerging business and will be well versed at helping to shape an organization’s culture.
  • Experience serving as an expert senior counselor and coach to the senior management team of a fast changing, dynamic and results-oriented organization.
  • Unquestioned integrity and ethics combined with the professional credibility and accountability to command respect and engender confidence across the organization.
  • Advanced degree, in human resources, organization development, or business, preferred.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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Informatics Developer, Research Infrastructure

We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we’ll develop for a range of severe diseases.

We are seeking a talented and highly motivated individual with experience working with informatics platforms in a laboratory setting to join our Research Infrastructure team. Good quality, reproducible data with all the associated meta-data is central to our research, and the successful candidate will play the role of Data Custodian responsible for providing tools to the scientists to ensure that data generated within the labs are promptly and accurately captured, analyzed and reported.

Your Role in Navigating The Maze:

  • You will work closely with scientists in identifying data streams that need to be captured and provide solutions that cater to their workflows.
  • Take responsibility for administering informatics platforms such as Electronic Lab Notebook (ELN), inventory and registration systems.
  • You will provide scientists with analysis routines and data monitoring dashboards.
  • Assist data scientists and computational scientists with tools for their workstreams.
  • Contribute to evaluating and deploying a centralized LIMS platform.
  • Work with the program leaders to develop data visualization interfaces that provide high-level aggregated visibility into program status and timelines.
  • You will work with automation engineers to define the format of data streams from instrumentation for capture into the LIMS platform.
  • You will collaborate with a multidisciplinary team to provide tools and solutions to ensure that all meta data associated with an experiment is captured appropriately to enable reproducibility of results.

Your Navigation Tools:

  • BS or MS in a scientific or engineering discipline with at least 3 years of experience in a biotechnology or pharmaceutical setting.
  • Experience with administering computer systems and data platforms (e.g. ELN, visualization platforms, chemical registration platforms).
  • Programming experience in Java, .NET, Python, R, Knime.
  • Wet lab experience running assays and recording procedures and data in platforms such as an ELN is a plus.
  • Innate attention to detail and ability to interface with colleagues from diverse disciplines to gather requirements and provide solutions.

If you’re ready to Enter The Maze, send your resume to careers@mazetx.com.

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The well-being of our employees and their families is important to us

We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.


Note to Recruitment Agencies: Please do not forward any agency resumes. Maze Therapeutics is not responsible for any fees related to resumes that are unsolicited.


Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.