Maze Therapeutics

working to translate genetic insights into effective precision medicines.

In the summer of 2018, we had an idea. A big idea, inspired by the recent dramatic advances in the field of genetics and the significant gaps in translating those into medicines. We set out to use these advances in harnessing the power of genetics to transform the lives of patients, which became our company’s mission.

Today, we are a clinical stage company developing small molecule precision medicines for common diseases with 3 clinical stage programs and several programs in drug discovery also being developed through the Maze Compass™ Platform.

Our Core Values

We live each day by our Maze values:

Further Together.

Impact Obsessed.

Stand True.

Leadership Team

Senior Management

Board of Directors

Jason Coloma, Ph.D.

Chief Executive Officer

Dr. Jason Coloma is the Chief Executive Officer of Maze Therapeutics. Prior to his appointment to CEO, he was Maze’s chief operating officer and a venture partner at Third Rock Ventures, where he was instrumental in the founding and launch…

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Herve Hoppenot

CHAIRMAN OF OUR BOARD OF DIRECTORS, CURRENT BOARD MEMBER and FORMER CEO OF INCYTE

Mr. Hoppenot joined Maze Therapeutics, Inc. as the Chairman of our board of directors in October 2025. Mr. Hoppenot currently serves on the board of directors of lncyte Corporation, where he has served since January 2014. He is also a…

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Charles Homcy, M.D.

FORMER CHAIRMAN OF THE MAZE BOARD, CHAIRMAN OF PHARMACEUTICALS AND LEAD DIRECTOR, BRIDGEBIO PHARMA

Charles Homcy, M.D., is a former partner at Third Rock Ventures. He is a co-founder of BridgeBio Pharma, Inc. and has served as a member of its board of directors since November 2018, as Chairman of Pharmaceuticals since February 2019,…

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Nancy Andrews, M.D., Ph.D

EXECUTIVE VICE PRESIDENT AND CHIEF SCIENTIFIC OFFICER, BOSTON CHILDREN’S HOSPITAL

Nancy Andrews, M.D., Ph.D., has extensive experience as a physician, scientist, professor and senior administrator at leading academic institutions and hospitals. Her distinguished career spans more than 30 years, with leadership roles at Harvard Medical School, Duke University, and Boston…

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Jonathan Lim, M.D.

Founder and managing partner, City Hill Ventures

Jonathan Lim, M.D., is the founder and managing partner at City Hill Ventures. In addition to his role at City Hill, Dr. Lim is a venture partner at ARCH Venture Partners, chairman, chief executive officer and co-founder at Erasca, and…

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Richard Scheller, Ph.D.

Former head of therapeutics and chief scientific officer, 23andMe

Dr. Richard Scheller is the former head of therapeutics and chief scientific officer of 23andMe. Prior to his role there, he spent 14 years at Genentech where he was executive vice president of research and early development. From 1982 to…

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Daniel K. Spiegelman

FORMER Executive Vice President, Chief Financial Officer, BIOMARIN PHARMACEUTICALS

Daniel K. Spiegelman has served as a chief financial officer in several diversified biotechnology companies spanning 30 years. He was most recently executive vice president and chief financial officer of BioMarin Pharmaceuticals, Inc., a pharmaceutical company focused on development of…

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Neil Kumar, Ph.D.

CEO and Founder, BridgeBio Pharma

Dr. Neil Kumar, Ph.D., is the CEO and Founder of BridgeBio Pharma, Inc. a company working to create life-altering medicines that target well-characterized genetic diseases at their source. He also launched GondolaBio in 2024. Prior to founding BridgeBio in 2015,…

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Paula Johnson, M.D., M.P.H.​

PRESIDENT, WELLESLEY COLLEGE AND CURRENT BOARD MEMBER OF JOHNSON & JOHNSON (J&J)​

Paul Johnson, M.D., M.P.H. is the President of Wellesley College, having served since 2016, and also currently serves on the Board of Directors of Johnson & Johnson (J&J). ​ Prior to Wellesely, Dr. Johnson founded and served as the inaugural Executive Director of the…

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Sophie Kornowski, Pharm.D., M.B.A.​

FORMER CEO, BOSTON PHARMACEUTICALS​

Dr. Kornowski has more than 35 years of biopharmaceutical leadership experience. Most recently, she served as Chief Executive Officer of Boston Pharmaceuticals beginning in 2022, focusing the company’s pipeline on candidates for liver disease and leading the company to its…

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OUR VISION IS TO BUILD THE NEXT GENERATION PRECISION MEDICINES COMPANY

Charles Homcy

M.D., CEO; Partner, Third Rock Ventures

Dr. Charles Homcy is a partner at Third Rock Ventures, where he focuses on the formation of companies that discover and develop novel therapeutic approaches. He brings significant experience building and leading successful biotech companies and has played an integral role in the launching and building of Third Rock Ventures’ portfolio companies, including Ambys Medicines, Global Blood Therapeutics, Pliant Therapeutics, Relay Therapeutics, Goldfinch Bio, CytomX and MyoKardia.

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